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PERSONALIZED BREAST CANCER MANAGEMENT USING
5-FLUOROURACIL AND RELATED BIOMARKERS:
A MOLECULAR BIOLOGY AND BUSINESS PERSPECTIVE
by
Radhika Shah
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOCHEMISTRY AND MOLECULAR BIOLOGY)
May 2009
Copyright 2009 Radhika Shah
Object Description
| Title | Personalized breast cancer management using 5-fluorouracil and related biomarkers: a molecular biology and business perspective |
| Author | Shah, Radhika |
| Author email | shahr@usc.edu; radhi.m@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biochemistry & Molecular Biology |
| School | Keck School of Medicine |
| Date defended/completed | 2009-01-28 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-03-16 |
| Advisor (committee chair) | Tokes, Zoltan |
| Advisor (committee member) |
Danenberg, Peter V. Olson, Thomas H. |
| Abstract | The scope of breast cancer management has expanded ever since the discovery of several key biomarkers that could predict predisposition, toxicity and pharmacokinetic responses in patients based on their genotype. Also the number of cases of adverse drug reactions that have been growing over the past few years especially related to the anti-cancer drug 5-fluorouracil, leading to an increasing number of trials using biomarkers to reduce toxicity. However there have been challenges faced by academia and the business world of biotech and pharmaceutical firms due to lack of synergy, murky regulations, high costs and lengthy time-frames of clinical approvals. This has hindered the actual growth of a market for pharmacodiagnostics and biomarkers on a global scale. This thesis examines biomarkers from a molecular biology standpoint to assess its importance and scope in enhancing individualized patient care. And from a business growth standpoint, this thesis presents the avenues where biomarkers can prove to be of profit potential for biotech and pharmaceutical firms, as well as examines the current pitfalls of the personalized cancer medicine market, with strategic case studies and recommendations. |
| Keyword | biomarker; 5-fluorouracil; breast cancer; business strategy |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2032 |
| Rights | Shah, Radhika |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Shah-2654 |
| Archival file | uscthesesreloadpub_Volume17/etd-Shah-2654.pdf |
Description
| Title | Page 1 |
| Full text | PERSONALIZED BREAST CANCER MANAGEMENT USING 5-FLUOROURACIL AND RELATED BIOMARKERS: A MOLECULAR BIOLOGY AND BUSINESS PERSPECTIVE by Radhika Shah A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOCHEMISTRY AND MOLECULAR BIOLOGY) May 2009 Copyright 2009 Radhika Shah |
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