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LESSONS LEARNED CONDUCTING A CLINICAL STUDY
by
Elizabeth Ogden Beale
_________________________________________________________________
A Thesis Presented to the
FACULTY OF THE KECK SCHOOL OF MEDICINE
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
May 2009
Copyright 2009 Elizabeth Ogden Beale
Object Description
| Title | Lessons learned conducting a clinical study |
| Author | Beale, Elizabeth Ogden |
| Author email | beale@usc.edu; sdemetri@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Preventive Medicine (Health Behavior) |
| School | Keck School of Medicine |
| Date defended/completed | 2008-12-12 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-03-13 |
| Advisor (committee chair) | Buchanan, Thomas A. |
| Advisor (committee member) |
Watanabe, Richard M. Xiang, Anny Hui |
| Abstract | Background. The aim of the Masters of Science in Clinical and Biomedical Investigations is for the candidate to develop the ability to conduct a real-world clinical study.; Aims of this thesis. To describe the problems encountered and the specific solutions identified in conducting a clinical study investigating genotype: phenotype relationships in type 2 diabetes and to derive generalizable principles to assist the candidate and other novice researchers in future research.; Method. The research is presented in typical format with the discussion focusing on an assessment of problems encountered and lessons learned.; Results. Several problems were encountered, particularly an inability to achieve target enrollment, unexpected results that were of debated cause and significance and a small sample size all of which limited the ability to confidently interpret the data.; Conclusion. Adequate sample size is central to confident data analysis and should increase the success of a clinical research study. |
| Keyword | type 2 diabetes; genetics; HNF4a; Mexican American; clinical study |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m2028 |
| Contributing entity | University of Southern California |
| Rights | Beale, Elizabeth Ogden |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@lib.usc.edu |
| Filename | etd-Beale-2593 |
| Archival file | uscthesesreloadpub_Volume17/etd-Beale-2593.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@lib.usc.edu |
| Full text | LESSONS LEARNED CONDUCTING A CLINICAL STUDY by Elizabeth Ogden Beale _________________________________________________________________ A Thesis Presented to the FACULTY OF THE KECK SCHOOL OF MEDICINE UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) May 2009 Copyright 2009 Elizabeth Ogden Beale |
