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NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, ANTI-ACID DRUGS
AND PASSIVE SMOKING AS IMPACT FACTORS FOR ESOPHAGEAL
AND GASTRIC ADENOCARCINOMAS
by
Lei Duan
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PREVENTIVE MEDICINE)
August 2008
Copyright 2008 Lei Duan
Object Description
| Title | Non-steroidal anti-inflammatory drugs, anti-acid drugs and passive smoking as impact factors for esophageal and gastric adenocarcinomas |
| Author | Duan, Lei |
| Author email | lduan@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Preventive Medicine (Health Behavior) |
| School | Keck School of Medicine |
| Date defended/completed | 2008-06-09 |
| Date submitted | 2008 |
| Restricted until | Restricted until 25 July 2010. |
| Date published | 2010-07-25 |
| Advisor (committee chair) | Bernstein, Leslie |
| Advisor (committee member) |
Chou, Chih-Ping Wu, Anna Reynolds, Kim Chandrasoma, Parakrama |
| Abstract | A dramatic increase in the incidence of esophageal adenocarcinoma has been observed in the United States and Western Europe during the past 3 decades. Likewise, a similar pattern of incidence although of smaller magnitude has also been observed for adenocarcinomas of the gastric cardia over the same period. Compared to 30 years ago, the rates of esophageal adenocarcinoma have increased more than 350%. In contrast, the incidence rates of the squamous cell carcinoma of the esophagus and adenocarcinoma of the distal stomach have remained static or even decreased. The underlying reasons for the increase in the incidence of adenocarcinoma of the esophagus and gastric cardia remain mostly unknown. Evidence suggests environmental exposures and host factors may play a very important role in this change. Studies have evaluated behavioral factors like tobacco and alcohol consumption, diet, obesity and physical activity as risk factors for many types of cancers as well as for adenocarcinomas of the esophagus and gastric cardia. While the existence of some medical conditions, such as Helicobacter pylori infection, Barrett's esophagus and gastro-esophageal reflux disease, and medications that were used to treat these diseases may be uniquely related with the risk of adenocarcinomas of the esophagus and gastric cardia.; This project examined the impact of behavioral factors, medical / biological factors and their interaction on the risk of esophageal and gastric adenocarcinomas. Specifically, we focused on passive smoking as a behavioral factor, and non-steroidal anti-inflammatory drugs and gastric acid suppression drugs as two medical / biological factors. Three studies were undertaken, Study One: Non-Steroidal Anti-Inflammatory Drugs and Risk of Esophageal and Gastric Adenocarcinomas in Los Angeles County, Study Two: Antacid Drugs and Risk of Esophageal and Gastric Adenocarcinomas in Los Angeles County, and Study Three: Passive smoking and Risk of Esophageal and Gastric Adenocarcinomas in Los Angeles County, to evaluate the risk factors andprotective factors for these cancers. This study used the data from a population-based case-control study lead by Dr. Leslie Bernstein. Incident cancer cases for this study were identified by the USC Cancer Surveillance Program (CSP). |
| Keyword | esophageal; gastric; ardenocarcinomas |
| Geographic subject (county) | Los Angeles County |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1414 |
| Rights | Duan, Lei |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Duan-20080725 |
| Archival file | uscthesesreloadpub_Volume32/etd-Duan-20080725.pdf |
Description
| Title | Page 1 |
| Full text | NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, ANTI-ACID DRUGS AND PASSIVE SMOKING AS IMPACT FACTORS FOR ESOPHAGEAL AND GASTRIC ADENOCARCINOMAS by Lei Duan A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PREVENTIVE MEDICINE) August 2008 Copyright 2008 Lei Duan |
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