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THE EFFECT OF TIDAL VOLUME ON MORTALITY AND VENTILATOR FREE
DAYS FOR CHILDREN WITH ACUTE LUNG INJURY (ALI)
by
Robinder G. Khemani
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
August 2008
Copyright 2008 Robinder G. Khemani
Object Description
| Title | The effect of tidal volume on mortality and ventilator free days for children with acute lung injury (ALI) |
| Author | Khemani, Robinder G. |
| Author email | rkhemani@chla.usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2008-08-01 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-07-24 |
| Advisor (committee chair) | Newth, Christopher J. L. |
| Advisor (committee member) |
Conti, David V. Alonzo, Todd Bart, Robert, III |
| Abstract | Objective: To determine whether Tidal Volume (Vt) between 6 and 10 ml/kg affects outcome for children with ALI.; Methods: Review of PICU admissions from 2000-2007. Inclusion criteria were intubation and ventilation with at least one PaO2/FiO2 ratio < 300.; Results: 398 patients were included. Overall mortality was 20% with a median Vt of 7.4 ml/kg. Median Vt on the first day of mechanical ventilation was lower in the group that died, although not statistically significant (p=0.06). After controlling for year, Delta P (PIP-PEEP), PEEP, and severity of lung disease, Vt was not associated with mortality (p>0.1), but higher Vt on day one of ventilation was associated with more ventilator free days (p<0.05). This was particularly true in patients with better respiratory compliance (OR=0.70, (0.52, 0.95)).; Conclusions: Between 6-10 ml/kg using pressure control ventilation, Vt early in mechanical ventilation is not associated with mortality, and higher Vt is associated with more ventilator free days. |
| Keyword | pediatrics; lung volume measurements; positive pressure respiration |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m1395 |
| Contributing entity | University of Southern California |
| Rights | Khemani, Robinder G. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Khemani-20080724 |
| Archival file | uscthesesreloadpub_Volume26/etd-Khemani-20080724.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | THE EFFECT OF TIDAL VOLUME ON MORTALITY AND VENTILATOR FREE DAYS FOR CHILDREN WITH ACUTE LUNG INJURY (ALI) by Robinder G. Khemani A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) August 2008 Copyright 2008 Robinder G. Khemani |
