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THE POLYMERIC IMMUNOGLOBULIN RECEPTOR IN OCULAR TISSUES
by
Wenzheng Zhang
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(PHARMACEUTICAL SCIENCES)
December 2006
Copyright 2006 Wenzheng Zhang
Object Description
| Title | The polymeric immunoglobulin receptor in ocular tissues |
| Author | Zhang, Wenzheng |
| Author email | zhangsunshine@yahoo.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Pharmaceutical Sciences |
| School | School of Pharmacy |
| Date defended/completed | 2006-08-24 |
| Date submitted | 2006 |
| Restricted until | Restricted until 12 Oct. 2008. |
| Date published | 2008-10-12 |
| Advisor (committee chair) | Okamoto, Curtis T. |
| Advisor (committee member) |
Mircheff, Austin K. Shen, Wei-Chiang Trousdale, Melvin D. Kim, Kwang-Jin |
| Abstract | Conjunctiva and lacrimal gland are two major ocular epithelial tissues included in the mucosal immunity system. The polymeric immunoglobulin receptor (pIgR) is expressed in a wide variety of secretory epithelial cells. The pIgR is the precursor to secretory component (SC) and secretory IgA (sIgA). It regulates secretion of SC and sIgA through its transcytosis across epithelial cells. The pIgR therefore plays an important role in mucosal immunity. To explore its role in ocular surface immunity, we sought to identify and characterize pIgR in ocular tissues.; In rabbit conjunctival epithelial cells, the pIgR and SC were molecularly identified and localized, which provide the potential of utilizing endogenously expressed pIgR for prevention of ocular surface-related diseases. Thus, a pIgR-based model of ocular mucosal immunity can be developed and characterized. In lacrimal gland acinar cells, we found that two members of small ras-like GTPases, rab3D (a regulated secretory vesicle marker) and rab11 (an apical endosome marker), are involved in the regulation of pIgR trafficking and therefore SC secretion in a stimulation-dependent manner. Furthermore, rab3D and rab11 may cross-talk in modulating pIgR trafficking through a regulated merocrine pathway and a constitutive transcytotic pathway, respectively, initiating a novel model of pIgR trafficking. |
| Keyword | polymeric immunoglobulin receptor; secretory component; conjunctival epithelium; lacrimal gland; rab3D; rab11 |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m92 |
| Rights | Zhang, Wenzheng |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Zhang-20061012 |
| Archival file | uscthesesreloadpub_Volume26/etd-Zhang-20061012.pdf |
Description
| Title | Page 1 |
| Full text | THE POLYMERIC IMMUNOGLOBULIN RECEPTOR IN OCULAR TISSUES by Wenzheng Zhang A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (PHARMACEUTICAL SCIENCES) December 2006 Copyright 2006 Wenzheng Zhang |
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