HEALTH-RELATED QUALITY OF LIFE IN PRESCHOOL CHILDREN WITH STRABISMUS OR AMBLYOPIA by Ge Wen ________________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) August 2009 Copyright 2009 Ge Wen
The Multi-Ethnic Pediatric Eye Disease Study (MEPEDS) was designed, in part, to explore the relationship between eye diseases and health-related quality of life (HRQOL) in young children.; The Pediatric Quality of Life Inventory (PedsQL), a measure of general HRQOL, was administered to the parents of a population-based sample of children aged 25 to 72 months in MEPEDS. It consists of 4 sub-scales (physical, emotional, social, and school functioning) and 3 composite scores (physical summary, psychosocial summary, and total scale). Children with strabismus or amblyopia were identified following a comprehensive eye examination. Regression models were used to evaluate the associations of HRQOL with strabismus or amblyopia in children ≧ 25 months and ≧ 30 months, respectively.; The results showed that strabismus was associated with statistically significantly lower HRQOL scores and amblyopia was not associated with any detectable decrease in general HRQOL in this young age group.