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CARDIORESPIRATORY VARIABILITY IN NORMAL AND SLEEP
DISORDERED BREATHING STATES:
A COMPREHENSIVE MODEL
by
Olga Vladimirovna Ivanova
___________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(BIOMEDICAL ENGINEERING)
December 2006
Copyright 2006 Olga Vladimirovna Ivanova
Object Description
| Title | Cardiorespiratory variability in normal and sleep disordered breathing states: a comprehensive model |
| Author | Ivanova, Olga Vladimirovna |
| Author email | oivanova@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Biomedical Engineering |
| School | Viterbi School of Engineering |
| Date defended/completed | 2006-06-12 |
| Date submitted | 2006 |
| Restricted until | Unrestricted |
| Date published | 2006-11-30 |
| Advisor (committee chair) | Khoo, Michael C.K. |
| Advisor (committee member) |
D'Argenio, David Z. Nakano, Aiichiro |
| Abstract | The dynamic interactions among the peripheral inputs that originate from the chemoreflexes, baroreflexes and pulmonary stretch receptors, together with central autonomic coupling between respiratory and cardiovascular efferents, play important roles in determining the physiological effects that accompany sleep apnea. However, previous modeling studies have focused primarily on specific regions of interest. The purpose of this research is to integrate key features of existing cardiovascular and respiratory models into a comprehensive model ("PNEUMA") capable of simulating the dynamics of cardiorespiratory control in wakefulness and sleep.; The model incorporates a realistic simulation of the wake-sleep cycle, which interacts with the respiratory and cardiovascular subsystems. PNEUMA's predictive capability is validated in both time and frequency domains by simulating physiological responses for different cardio-respiratory states, such as Valsalva breathing maneuver, hypoxia and hypercapnia, obstructive and central sleep apneas, Cheyne-Stokes respiration that emerge spontaneously from combined interaction of separate control systems, as they do in the real patient.; A secondary goal of this study was the investigation of the cardiorespiratory regulation mechanisms leading to heart rate and blood pressure fluctuations during sleep in conditions with normal and disordered breathing. Spectral analyses of the model-simulated variability in heart rate and blood pressure suggest that our model correctly accounts for the key aspects of autonomic cardiovascular control.; The comprehensive cardiorespiratory model is implemented using SIMULINK® (The Mathworks, Natick, MA). The advantages of this form of implementation lie in its modularity, flexibility and platform-independence. |
| Keyword | physiological model simulation; autonomic pathways and reflexes; circadian cycle; sleep modeling; sleep disordered breathing |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m205 |
| Contributing entity | University of Southern California |
| Rights | Ivanova, Olga Vladimirovna |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Ivanova-20061130 |
| Archival file | uscthesesreloadpub_Volume48/etd-Ivanova-20061130.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | CARDIORESPIRATORY VARIABILITY IN NORMAL AND SLEEP DISORDERED BREATHING STATES: A COMPREHENSIVE MODEL by Olga Vladimirovna Ivanova ___________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (BIOMEDICAL ENGINEERING) December 2006 Copyright 2006 Olga Vladimirovna Ivanova |
