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THE MOLECULAR MECHANISM REGULATING THE TIMING OF CELL
CYCLE EXIT DURING DEVELOPMENT OF THE MOUSE
ORGAN OF CORTI
by
Feng Liu
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(NEUROSCIENCE)
May 2007
Copyright 2007 Feng Liu
Object Description
| Title | The molecular mechanism regulating the timing of cell cycle exit during development of the mouse organ of Corti |
| Author | Liu, Feng |
| Author email | liuf@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Neuroscience |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2006-12-04 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-02-14 |
| Advisor (committee chair) | Segil, Neil |
| Advisor (committee member) |
Swanson, Larry Arnold, Donald Ko, Chien-Ping Maxson, Robert |
| Abstract | During development of the cochlea, cells within the prospective prosensory domain undergo a wave of cell cycle exit, which defines the number of postmitotic sensory progenitors giving rise to the hair cells and supporting cells of the organ of Corti. Previous studies indicated that p27 (Kip1), a cyclin-dependent kinase inhibitor, is required for the timely cell cycle exit of sensory progenitors. However, how the pattern of p27 expression is established in development, and how the timing of cell cycle exit affects morphogenesis of the organ of Corti have not been fully investigated.; Studies described here indicate that p27 expression is upregulated within the prosensory domain in an apical-to-basal wave to direct the cell cycle exit of sensory progenitors. Moreover, the precise timing of p27 protein accumulation in the cochlea is dependent on both transcriptional and post-translational mechanisms, which collaborate to ensure the precise timing of cell cycle exit. Finally, correct timing of the p27-dependent cell cycle exit is critical for producing the normal number of cells that is required for the morphogenesis and function of the organ of Corti. Together, this study demonstrates a mechanism that couples cell number control with organ of Corti morphogenesis. |
| Keyword | mouse; organ of Corti; inner ear; p27Kip1; cell cycle; development |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m257 |
| Rights | Liu, Feng |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Liu-20070214 |
| Archival file | uscthesesreloadpub_Volume29/etd-Liu-20070214.pdf |
Description
| Title | Page 1 |
| Full text | THE MOLECULAR MECHANISM REGULATING THE TIMING OF CELL CYCLE EXIT DURING DEVELOPMENT OF THE MOUSE ORGAN OF CORTI by Feng Liu A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (NEUROSCIENCE) May 2007 Copyright 2007 Feng Liu |
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