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TELOMERASE EXPRESSION AS A MARKER FOR MINIMAL RESIDUAL DISEASE DETECTION IN PATIENTS UNDERGOING SECOND-LOOK LAPAROTOMY FOR OVARIAN CANCER: A FOLLOW-UP STUDY
by
Lindsey Hughes
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(EXPERIMENTAL AND MOLECULAR PATHOLOGY)
May 2007
Copyright 2007 Lindsey Hughes
Object Description
| Title | Telomerase expression as a marker for minimal residual disease detection in patients undergoing second-look laparotomy for ovarian cancer: a follow-up study |
| Author | Hughes, Lindsey D. |
| Author email | lindseydhughes@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Experimental & Molecular Pathology |
| School | Keck School of Medicine |
| Date defended/completed | 2007-01-23 |
| Date submitted | 2007 |
| Restricted until | Unrestricted |
| Date published | 2007-02-18 |
| Advisor (committee chair) | Dubeau, Louis |
| Advisor (committee member) |
Hong, Hao Ladner, Robert D. [?] Wu, Anna |
| Abstract | We hypothesized that telomerase positivity in abdominal washings from patients undergoing a second-look procedure is a predictor of disease recurrence.; Follow-up data was obtained from 68 patients in whom the presence or absence of telomerase activity was examined in abdominal washings at the time of their second-look procedures. There was no association between telomerase expression and time to recurrence or time to death among the cases with negative second-look findings. Telomerase expression among patients with positive second-look was not statistically different when comparing time to death. No association can be made when comparing time to death and telomerase expression among all patients.; We conclude that telomerase may not be an accurate predictor of residual disease and survival among patients with ovarian cancer who are clinically free of disease after initial surgery and first-line chemotherapy. |
| Keyword | telomerase; TRAP; residual disease detection; biomarker; ovarian cancer |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Type | texts |
| Legacy record ID | usctheses-m279 |
| Rights | Hughes, Lindsey D. |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Hughes-20070218 |
| Archival file | uscthesesreloadpub_Volume40/etd-Hughes-20070218.pdf |
Description
| Title | Page 1 |
| Full text | TELOMERASE EXPRESSION AS A MARKER FOR MINIMAL RESIDUAL DISEASE DETECTION IN PATIENTS UNDERGOING SECOND-LOOK LAPAROTOMY FOR OVARIAN CANCER: A FOLLOW-UP STUDY by Lindsey Hughes A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (EXPERIMENTAL AND MOLECULAR PATHOLOGY) May 2007 Copyright 2007 Lindsey Hughes |
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