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A CONE BEAM-CT EVALUATION OF THE UPPER AIRWAY
FOR SLEEP APNEA PREDICTION
by
Maria Reyes Enciso Cachafeiro
____________________________________________________________________
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CLINICAL AND BIOMEDICAL INVESTIGATIONS)
May 2009
Copyright 2009 Maria Reyes Enciso Cachafeiro
Object Description
| Title | A cone beam-CT evaluation of the upper airway for sleep apnea prediction |
| Author | Cachafeiro, Maria Reyes Enciso |
| Author email | renciso@usc.edu; encisor@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Clinical & Biomedical Investigations |
| School | Keck School of Medicine |
| Date defended/completed | 2008-12-04 |
| Date submitted | 2009 |
| Restricted until | Unrestricted |
| Date published | 2009-02-12 |
| Advisor (committee chair) | Azen, Stanley |
| Advisor (committee member) |
Clark, Glenn T. Xiang, Anny |
| Abstract | Introduction: Cephalometric and other imaging modalities have been used to compare Obstructive Sleep Apnea (OSA) patients with controls, but volumetric measurements of the upper airway are scarce. Purpose: To compare the Cone-Beam Computerized Tomography (CBCT) scan measurements between patients with OSA and controls to develop a prediction model for OSA based on imaging and family history. Methods: 39 OSA patients (Apnea-Hypoapnea Index≥15) and 23 controls based on ambulatory somnographic assessment were recruited through flyers and mail at USC School of Dentistry. Each patient answered the Berlin Questionnaire, collected family member’s Berlin Questionnaires and was imaged with CBCT. Linear and volumetric measurements of the upper airway were performed and multivariate logistic regression analysis was used to identify risk factors for OSA. Results: OSA patients were predominantly male, older, had a larger neck size and larger Body Mass index than controls. The minimum cross-sectional area and the lateral dimension were significantly smaller in cases. Conclusions: Age>57 years, male gender, a positive Berlin (or ARES Questionnaire) and narrow upper airway lateral dimension were identified as significant risk factors for OSA. This prediction model for OSA could be implemented based on this work, however further studies are needed to generalize our findings. Limitations of the study include self-selection bias for the controls: subjects with a positive family history of sleep apnea are more willing to participate in a study to predict OSA based on family history, so the odds-ratios of having OSA based on family history were underestimated. |
| Keyword | sleep apnea; cone-beam CT; imaging; prediction; family history |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1974 |
| Rights | Cachafeiro, Maria Reyes Enciso |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Cachafeiro-2574 |
| Archival file | uscthesesreloadpub_Volume32/etd-Cachafeiro-2574.pdf |
Description
| Title | Page 1 |
| Full text | A CONE BEAM-CT EVALUATION OF THE UPPER AIRWAY FOR SLEEP APNEA PREDICTION by Maria Reyes Enciso Cachafeiro ____________________________________________________________________ A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CLINICAL AND BIOMEDICAL INVESTIGATIONS) May 2009 Copyright 2009 Maria Reyes Enciso Cachafeiro |
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