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ROLE OF HEPATITIS C VIRUS F PROTEIN IN VIRAL PROTEIN EXPRESSION AND RNA REPLICATION
by
Cheng-Fu Kuo
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(MOLECULAR BIOLOGY AND IMMUNOLOGY)
December 2008
Copyright2008 Cheng-Fu Kuo
Object Description
| Title | Role of hepatitis C virus F protein in viral protein expression and RNA replication |
| Author | Kuo, Cheng-Fu |
| Author email | chengfuk@usc.edu; chengfuk@usc.edu |
| Degree | Master of Science |
| Document type | Thesis |
| School | Keck School of Medicine |
| Date defended/completed | 2008-06-22 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-12-12 |
| Advisor (committee chair) | Ou, James |
| Advisor (committee member) |
Schönthal, Axel Kalra, Vijay |
| Abstract | Programmed ribosomal frameshift is a novel mechanism used by virus to translate protein from 0 reading frame to -2/+1 reading frame. An A-rich slippery sequence and a pseudoknot RNA structure located at 5’end of core coding region constitute a signal for ribosomal frameshift. Hepatitis C virus (HCV) uses such a mechanism to produce F protein from -2/+1 reading frame. However, the function of F is still unclear. In this study, we examined the possible functions of F protein in HCV life cycle. We found that HCV without expressing F protein has poor RNA replication and impaired virus assembly, releasing and infectivity. Our results suggest that F protein has a possible function of regulating RNA replication and maturation process of virus. This observation could give us an idea to develop antiviral therapy. |
| Keyword | hepatitus C virus; frameshift |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1923 |
| Rights | Kuo, Cheng-Fu |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Kuo-2546 |
| Archival file | uscthesesreloadpub_Volume23/etd-Kuo-2546.pdf |
Description
| Title | Page 1 |
| Full text | ROLE OF HEPATITIS C VIRUS F PROTEIN IN VIRAL PROTEIN EXPRESSION AND RNA REPLICATION by Cheng-Fu Kuo A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (MOLECULAR BIOLOGY AND IMMUNOLOGY) December 2008 Copyright2008 Cheng-Fu Kuo |
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