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PALLADIUM MEDIATED METHODS FOR THE TOTAL SYNTHESIS OF LIPID
MEDIATORS AND ORGANOBORON COMPOUNDS
by
Kalyan Chakravarthy Nagulapalli Venkata
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(CHEMISTRY)
December 2008
Copyright 2008 Kalyan Nagulapalli Venkata
Object Description
| Title | Palladium mediated methods for the total synthesis of lipid mediators and organoboron compounds |
| Author | Venkata, Kalyan Chakravarthy Nagulapalli |
| Author email | nvkalyan@gmail.com; nagulapa@usc.edu |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Chemistry |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2008-09-11 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-12-09 |
| Advisor (committee chair) | Petasis, Nicos A. |
| Advisor (committee member) |
Prakash, G.K. Surya Neamati, Nouri |
| Abstract | This dissertation deals with synthetic and conformational studies of biologically important compounds.; Chapter 1 is overview of lipid mediators that possess anti-inflammatory and promote resolution. The different varieties of lipid mediators and biological activities are reviewed in this chapter.; Chapter 2 describes our efforts in the area of design, synthesis and conformational studies of lipoxins and benzo-lipoxin analogs. These compounds are resistant to physical and metabolic properties. They have important properties as anti-inflammatory agents that are easy to synthesize and handle.; Chapter 3 details an efficient method for the synthesis of allyl boronates from allyl bromides by utilizing bis(pinacolato) diboron as borylating reagent. This chapter describes the Petasis three component reaction for the synthesis of γ, δ-unsaturated amino acids, that possess important biological properties.; Chapter 4 first surveys the current available methods for synthesis of organoboron compounds. A novel palladium mediated method for the conversion of alkenes into alkenyl and alkyl boronates is reported. A new conjugate addition reaction of diboron compounds with activated alkenes catalyzed by palladium is reported in this chapter. |
| Keyword | conformational studies of lipoxins; benzolipoxins; organoboron compounds synthesis |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1900 |
| Contributing entity | University of Southern California |
| Rights | Venkata, Kalyan Chakravarthy Nagulapalli |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | cisadmin@dots.usc.edu |
| Filename | etd-Venkata-2457 |
| Archival file | uscthesesreloadpub_Volume14/etd-Venkata-2457.pdf |
Description
| Title | Page 1 |
| Contributing entity | University of Southern California |
| Repository email | cisadmin@dots.usc.edu |
| Full text | PALLADIUM MEDIATED METHODS FOR THE TOTAL SYNTHESIS OF LIPID MEDIATORS AND ORGANOBORON COMPOUNDS by Kalyan Chakravarthy Nagulapalli Venkata A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (CHEMISTRY) December 2008 Copyright 2008 Kalyan Nagulapalli Venkata |
