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AUTOPHAGY AND HEPATITIS C AND HEPATITIS B VIRUSES
by
Donna Sir
________________________________________________________________________
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
DOCTOR OF PHILOSOPHY
(MOLECULAR MICROBIOLOGY AND IMMUNOBIOLOGY)
December 2008
Copyright 2008 Donna Sir
Object Description
| Title | Autophagy and Hepatitis C and Hepatitis B viruses |
| Author | Sir, Donna |
| Author email | dsir@usc.edu; donnasir@gmail.com |
| Degree | Doctor of Philosophy |
| Document type | Dissertation |
| Degree program | Molecular Microbiology & Immunology |
| School | Keck School of Medicine |
| Date defended/completed | 2008-10-24 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-12-09 |
| Advisor (committee chair) | Ou, James |
| Advisor (committee member) |
Tahara, Stanley M. Mosteller, Raymond |
| Abstract | Hepatitis C virus (HCV) and Hepatitis B virus (HBV) are both major health problems. Together HCV and HBV are the leading causes of chronic liver disease and the most common indication for liver transplantation in the world. In the US, chronic liver disease is the tenth leading cause of death with 40% to 60% due to HCV infection. In China, HBV is more prevalent and accounts for 90% of liver transplantations and liver disease. To date there are no vaccines for HCV. For HBV, although the number of HBV infections has been reduced by the use of the HBV vaccine, there is still a large group of people who suffer from HBV infection. Therefore, the need to understand these viruses and develop safe and effective treatments is paramount.; In these studies, I have looked at how HCV and HBV subvert autophagy, an innate immune response for the removal of intracellular pathogens (Kirkegaard et al.,2004), for their own use. In this dissertation, I showed through a series of biochemical and molecular biological assays that both HCV and HBV induce autophagosomalformation, however both through very different mechanisms. The outcome is similar between these two viruses in that the induction of autophagosomes is both beneficial to the viruses. These unexpected effects of HCV and HBV on the host cell likely play an important role in HCV and HBV pathogenesis. |
| Keyword | Hepatitis B virus; Hepatitis C virus; autophagy; autophagosomes; endoplasmic reticulum stress; HBV X protein |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1903 |
| Rights | Sir, Donna |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Sir-2492 |
| Archival file | uscthesesreloadpub_Volume14/etd-Sir-2492.pdf |
Description
| Title | Page 1 |
| Full text | AUTOPHAGY AND HEPATITIS C AND HEPATITIS B VIRUSES by Donna Sir ________________________________________________________________________ A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree DOCTOR OF PHILOSOPHY (MOLECULAR MICROBIOLOGY AND IMMUNOBIOLOGY) December 2008 Copyright 2008 Donna Sir |
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