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CHARACTERIZING THE PROTEIN EXPRESSION OF S1P RECEPTORS IN
T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) CELL LINES
by
Yue Zhang
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(CRANIOFACIAL MOLECULAR BIOLOGY)
December 2008
Copyright 2008 Yue Zhang
Object Description
| Title | Characterizing the protein expression of S1P receptors in T-cell acute lymphoblastic leukemia (T-ALL) cell lines |
| Author | Zhang, Yue |
| Author email | yuez@usc.edu; alan_chen_1977@hotmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Cranio-Facial Biology |
| School | School of Dentistry |
| Date defended/completed | 2008-10-31 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-12-10 |
| Advisor (committee chair) | Paine, Michael |
| Advisor (committee member) |
Maurer, Barry Mosteller, Raymond Zeichner-David, Margarita |
| Abstract | The implication of S1P in cancer has attracted researchers from a wide spectrum of fields, but the relationship between S1P and leukemia has not been well studied, with limited data indicating a possible anti-apoptotic and pro-survival role of S1P that may lead to drug resistance. The current thesis aims at a characterization of the expression profile of S1P receptors in T-cell ALL leukemia using western blot analysis. It is hypothesized that one or more S1P receptors are expressed in a panel of T-ALL cell lines so that S1P-induced signals are transduced by these receptors. We expect that western blot analysis can detect the expression of these receptors. This project will lay the groundwork for the future research on S1P signaling pathways in T-ALL cell lines and may potentially provide more target molecules for drug development against T-cell ALL. |
| Keyword | acute lymphoblastic leukemia; sphingosine 1 phosphate receptor; western blots |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1905 |
| Rights | Zhang, Yue |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Zhang-2530 |
| Archival file | uscthesesreloadpub_Volume14/etd-Zhang-2530.pdf |
Description
| Title | Page 1 |
| Full text | CHARACTERIZING THE PROTEIN EXPRESSION OF S1P RECEPTORS IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (T-ALL) CELL LINES by Yue Zhang A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (CRANIOFACIAL MOLECULAR BIOLOGY) December 2008 Copyright 2008 Yue Zhang |
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