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THE EFFECTS OF SAMPLE SIZE ON HAPLOTYPE BLOCK PARTITION, TAG SNP
SELECTION AND POWER OF GENETIC ASSOCIATION STUDIES
by
Li Wang
A Dissertation Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(STATISTICS)
December 2008
Copyright 2008 Li Wang
Object Description
| Title | The effects of sample size on haplotype block partition, tag SNP selection and power of genetic association studies |
| Author | Wang, Li |
| Author email | wang7@usc.edu; tujiaojiao1981@gmail.com |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Statistics |
| School | College of Letters, Arts and Sciences |
| Date defended/completed | 2008-10-25 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-12-09 |
| Advisor (committee chair) | Goldstein, Larry |
| Advisor (committee member) |
Chen, Ting Chen, Liang |
| Abstract | Recent studies have shown that linkage disequilibrium (LD) varies significantly across the human genome, with interspersed regions of high and low LD. In regions of high LD, a fraction of single nucleotide polymorphisms (SNP), tag SNPs, can be used to capture most of the haplotype information. We study the reliability of haplotype block partitioning and tag SNP selection, and the power of the association studies with tag SNPs based on actual data from a large number of 834 Caucasians genotyped with 97 SNPs in 3 regions with distinct LD patterns. We first assess the effect of sample size on haplotype block partitioning and tag SNP selection and show that 40-50 unrelated Caucasians are sufficient for reliable partitioning of haplotype blocks and selection of tag SNPs. We then compare the power of association studies using tag SNPs selected by differing criteria. |
| Keyword | tag SNP; haplotype; sample size; association study |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1897 |
| Rights | Wang, Li |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Wang-2505 |
| Archival file | uscthesesreloadpub_Volume48/etd-Wang-2505.pdf |
Description
| Title | Page 1 |
| Full text | THE EFFECTS OF SAMPLE SIZE ON HAPLOTYPE BLOCK PARTITION, TAG SNP SELECTION AND POWER OF GENETIC ASSOCIATION STUDIES by Li Wang A Dissertation Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (STATISTICS) December 2008 Copyright 2008 Li Wang |
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