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PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS
INFECTION PREDICTED BY CLUSTERED PROFILES OF
IMMUNE ACTIVATION MARKERS
by
Tracey Lynn Stiller
A Thesis Presented to the
FACULTY OF THE GRADUATE SCHOOL
UNIVERSITY OF SOUTHERN CALIFORNIA
In Partial Fulfillment of the
Requirements for the Degree
MASTER OF SCIENCE
(BIOSTATISTICS)
December 2008
Copyright 2008 Tracey Lynn Stiller
Object Description
| Title | Progression of human immunodeficiency virus infection predicted by clustered profiles of immune activation markers |
| Author | Stiller, Tracey Lynn |
| Author email | tracey.stiller@gmail.com; tstiller@coh.org |
| Degree | Master of Science |
| Document type | Thesis |
| Degree program | Biostatistics |
| School | Keck School of Medicine |
| Date defended/completed | 2008-09-12 |
| Date submitted | 2008 |
| Restricted until | Unrestricted |
| Date published | 2008-10-15 |
| Advisor (committee chair) | Mack, Wendy |
| Advisor (committee member) |
Kovacs, Andrea Karim, Roksana |
| Abstract | Evidence shows that CD4+ and CD8+ T-cells, including CD8+CD38+ and CD4+CD38+DR+, are associated with risk of developing AIDS among HIV-positive individuals. While immune activation markers have been shown to individually effect progression to AIDS it is not known how profiles of immune markers effect progression.; In this study, cluster analysis was used to group HIV-infected women with similar profiles of CD4+ and CD8+ T-cells with activation markers CD38 and DR. Cox regression was used to assess the effect of immune activation profiles on progression to AIDS in univariate and multivariate models.; The cluster analysis resulted in 4 distinct immune marker profiles. Clusters associated with high percentages of CD4+CD38+DR+, CD8+CD38+DR+ or CD4+CD38+DR+, CD8+CD38+DR- showed an increased AIDS risk compared to clusters with high percentages of CD4+CD38+DR-, CD8+CD38+DR- or CD4+CD38-DR-, CD8+CD38-DR-, but hold only for comparing CD4+CD38+DR+, CD8+CD38+DR+ to CD4+CD38+DR-, CD8+CD38+DR- when adjusted for HIV RNA, and none hold for CD4 count. |
| Keyword | cluster analysis; immune activation; AIDS; HIV |
| Language | English |
| Part of collection | University of Southern California dissertations and theses |
| Publisher (of the original version) | University of Southern California |
| Place of publication (of the original version) | Los Angeles, California |
| Publisher (of the digital version) | University of Southern California. Libraries |
| Provenance | Electronically uploaded by the author |
| Type | texts |
| Legacy record ID | usctheses-m1669 |
| Rights | Stiller, Tracey Lynn |
| Repository name | Libraries, University of Southern California |
| Repository address | Los Angeles, California |
| Repository email | http://www.usc.edu/isd/libraries/services/ask_a_librarian/email/ |
| Filename | etd-Stiller-2412 |
| Archival file | uscthesesreloadpub_Volume29/etd-Stiller-2412.pdf |
Description
| Title | Page 1 |
| Full text | PROGRESSION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION PREDICTED BY CLUSTERED PROFILES OF IMMUNE ACTIVATION MARKERS by Tracey Lynn Stiller A Thesis Presented to the FACULTY OF THE GRADUATE SCHOOL UNIVERSITY OF SOUTHERN CALIFORNIA In Partial Fulfillment of the Requirements for the Degree MASTER OF SCIENCE (BIOSTATISTICS) December 2008 Copyright 2008 Tracey Lynn Stiller |
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